CB2 Receptor: Immune & Peripheral Systems
• Localization: Cerebral cortex, cerebellum, dorsal horn
• Mechanism: Presynaptic G_i/o inhibition of glutamate/GABA
• Primary Role: Central pain gating & synaptic retrograde feedback
• Localization: Microglia, splenocytes, peripheral nerve terminals
• Mechanism: Downregulation of pro-inflammatory cytokines
• Primary Role: Peripheral inflammation & immunomodulation
Species-Specific Variations & Functional Neuroanatomy
• Canine: Cerebellar CB1 density creates static ataxia vulnerability.
• Feline: Peripheral CB2 profile requires specialized dosing protocols.