Australia's hemp pet pioneer since 2018  •  Veterinary CE Course
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Module 2

Module 2: Endogenous Ligands & Metabolism

Comparative Biosynthesis, Synaptic Pathways & Enzymatic Clearance

Endocannabinoid Ligands & Metabolism

AEA Profile
• Partial CB1/CB2 agonist
• NAPE-PLD synthesis
• Cleared by FAAH enzyme
• Low basal brain levels
2-AG Profile
• Full CB1/CB2 agonist
• DAGL-mediated synthesis
• Cleared by MAGL enzyme
• High basal brain levels
Retrograde Signaling
• On-demand Ca2+ synthesis
• Retrograde CB1 binding
• Suppresses NT release
Therapeutic Modulation
• FAAH blockade boosts AEA
• MAGL blockers boost 2-AG
• Minimises CB1 tolerance

Clinical Disclaimer

This course is for veterinary continuing education. It does not constitute veterinary advice or a recommendation to prescribe any specific product. No therapeutic claims are made for unapproved products.